Xyrio 20mg 4 Tablets

What Tadalafil is used for

• Tadalafil is a treatment for adult men with erectile dysfunction.
• This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity.
• Tadalafil has been shown to significantly improve the ability of obtaining a hard-erect penis suitable for sexual activity.
• Tadalafil belongs to a group of medicines called phosphodiesterase type 5 inhibitors.
• Following sexual stimulation Tadalafil works by helping the blood vessels in your penis to relax, allowing the flow of blood into your penis.
• The result of this is improved erectile function. Tadalafil will not help you if you do not have erectile dysfunction.
• It is important to note that Tadalafil does not work if there is no sexual stimulation.

Do not take Tadalafil if you:

• are allergic to tadalafil or any of the other ingredients of this medicine.
• have serious heart disease or recently had a heart attack within the last 90 days.
• recently had a stroke within the last 6 months.
• have low blood pressure or uncontrolled high blood pressure.
• ever had loss of vision because of non-arteritic anterior ischemic optic neuropathy, a

• condition described as “stroke of the eye”.

Warnings and precautions:

Before taking the tablets, tell your doctor if you have:

• sickle cell anemia (an abnormality of red blood cells).
• multiple myeloma (cancer of the bone marrow).
• leukemia (cancer of the blood cells).
• any deformation of your penis.
• a serious liver problem.
• a severe kidney problem.

Possible side effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them.
• These effects are normally mild to moderate in nature.

If you experience any of the following side effects stop using the medicine and seek medical help immediately:

• allergic reactions including rashes.
• chest pain – do not use nitrates but seek immediate medical assistance.
• priapism, a prolonged and possibly painful erection after taking Tadalafil. If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately.
• sudden loss of vision.

Other side effects have been reported:

• headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion.
• dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired.
• fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating.

Other medicines and Tadalafil

Tell your doctor if you are taking, have recently taken or might take any other medicines

Do not take Tadalafil if you are already taking nitrates.

Some medicines may be affected by Tadalafil or they may affect how well Tadalafil will work including:

• an alpha blocker (used to treat high blood pressure or urinary symptoms associated with benign

prostatic hyperplasia).

• other medicines to treat high blood pressure.
• A-5-Alpha reductase inhibitor (used to treat benign prostatic hyperplasia).
• medicines such as ketoconazole tablets (to treat fungal infections) and protease inhibitors for treatment of AIDS or HIV infection.
• phenobarbital, phenytoin and carbamazepine (anticonvulsant medicines).
• rifampicin, erythromycin, clarithromycin or itraconazole.
• other treatments for erectile dysfunction.

How to take Tadalafil

• Always take this medicine exactly as your doctor has told you.
• Check with your doctor or pharmacist if you are not sure.
• Tadalafil tablets are for oral use in men only.
• Swallow the tablet whole with some water.
• The tablets can be taken with or without food.
• The recommended starting dose is one 10 mg tablet before sexual activity.
• However, you have been given the dose of one 20mg tablet as your doctor has decided that the recommended dose of 10mg is too weak.
• You may take a Tadalafil tablet at least 30 minutes before sexual activity.
• Tadalafil may still be effective up to 36 hours after taking the tablet.
• Do not take Tadalafil more than once a day.
• Tadalafil 10 mg and 20 mg is intended for use prior to anticipated sexual activity and is not recommended for continuous daily use.

How to store Tadalafil

• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the carton and blister after ‘EXP’. The expiry date refers to the last day of that month.
• Store in the original package in order to protect from moisture.
• Do not store above 30°C.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.